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Home > Services > Biostatistics
Biostatistics
The GCRC Biostatistics Core offers investigators help in planning clinical studies:
- study design, treatments and stratification
- pharmacokinetic and pharmacodynamic studies
- gene mapping and microarray studies
- randomization plans
- stopping rules for adverse effects,
- sample size and power calculations,
- data analysis plans,
- data management plans.
The GCRC’s main biostatistician is William Thomas, Associate Professor in the Biostatistics Division, School of Public Health. He can be reached at 625-0651, fax 626-0660, or email: will@biostat.umn.edu. He has worked with many clinical investigators at the GCRC since 1992.
If you would like specialized assistance in the area of forecasting drug response, you may contact Richard Brundage, Associate Professor in the College of Pharmacy. He can be reached at 624-3115 or brund001@umn.edu.
Understanding and identifying pharmacologic variability in drug responsiveness is a primary challenge facing investigators interested in therapeutic trials. Dr. Brundage directs the Center for Forecasting Drug Response to meet this need by working with investigators to develop appropriate methodology suitable for their project. One approach will be to suggest ways to incorporate pharmacokinetic and pharmacodynamic studies into therapeutic clinical studies, an opportunity too commonly missed in clinical research studies. Dr. Brundage can advise on experimental design, the choice of compartmental modeling or noncompartmental data analysis methods, and the use of a standard two-stage approach or a population pharmacokinetic analysis.
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